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Evolutionary Coupling Analysis

Predicted and experimental contacts

Interactive contact map

Secondary structure from ECs

Known pdb structures

pdb chain
1e5w A
1ef1 C

EC score distribution and threshold

Top ECs

Rank Residue 1 Amino acid 1 Residue 2 Amino acid 2 EC score
1 466 A 470 P 0.61
2 538 K 543 M 0.58
3 463 L 467 M 0.51
4 477 E 481 D 0.50
5 478 N 482 E 0.49
6 465 T 473 A 0.45
7 530 A 535 E 0.44
8 462 E 466 A 0.43
9 539 T 543 M 0.43
10 472 V 476 A 0.43
11 490 A 494 L 0.43
12 541 N 545 H 0.42
13 535 E 541 N 0.42
14 525 L 529 L 0.42
15 536 S 542 D 0.41
16 539 T 545 H 0.40
17 496 A 500 A 0.40
18 525 L 531 N 0.39
19 464 K 468 S 0.39
20 480 Q 484 D 0.39
21 495 R 499 M 0.39
22 465 T 469 T 0.39
23 528 E 532 A 0.39
24 481 D 489 E 0.39
25 480 Q 487 G 0.39
26 514 K 522 L 0.38
27 524 A 539 T 0.38
28 533 R 537 K 0.37
29 531 N 541 N 0.37
30 476 A 480 Q 0.37
31 490 A 496 A 0.37
32 531 N 539 T 0.37
33 470 P 474 E 0.36
34 510 T 514 K 0.36
35 516 E 520 K 0.36
36 525 L 532 A 0.35
37 533 R 540 A 0.35
38 536 S 543 M 0.35
39 461 A 465 T 0.35
40 537 K 543 M 0.34
41 467 M 471 H 0.34
42 524 A 535 E 0.34
43 529 L 533 R 0.34

Alignment robustness analysis

First most common residue correlation

Second most common residue correlation

Robustness